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Scientific Program

  • Nov. 12, 2017 (Sun)
  • Nov. 13, 2017 (Mon)
  • Nov. 14, 2017 (Tue)
  • Nov. 15, 2017 (Wed)
  • Nov. 16, 2017 (Thu)

Educational Course

Workshop 1
(WS01)
* Only for Korean
일정 2017년 11/12(일), 13:00-15:00 Room 113 (1F)  
등록비 일반 : 150,000원, 학생: 100,000원
* 등록 페이지에서 함께 신청하실 수 있습니다.
Introduction to Human Health Risk Assessment (인체 위해성평가 개론)
Kyu-Bong Kim (Dankook University) / 김규봉 (단국대학교)
 
Hazard Identification and dose-response assessment (Case Study) (유해성 및 용량 반응 평가 (실전 응용 강의))
Seung Jun Kwack (Changwon National University) / 곽승준 (창원대학교)
 
Exposure Assessment and Risk Characterization (Case Study) (노출평가 및 위해도 결정 (실전 응용 강의))
Kyu-Bong Kim (Dankook University / 김규봉 (단국대학교)
Workshop 2
(WS02)
Date / Time Nov 12 (Sun), 2017, 15:00-17:00 Room 113 (1F)  
Registration Fee Professional : $150, Student : $100
* You can register for the Educational Course at the online registration page.
Risk Assessment of Genotoxic and Non-Genotoxic Carcinogens   Summery
Takehiko Nohmi (NIHS, Japan)
Why DNA Damage Matters to Your Health and How Nutrition Can Help You to Prevent it
Michael Fenech (CSIRO Health and Biosecurity, Australia)
Mutational Spectra and Signatures   Summery
David Phillips (King's College London, UK)

Opening Ceremony

Opening Ceremony Date / Time Nov 12 (Sun), 2017, 17:00-17:30 Room Premier Ballroom (2F)  
Opening Ceremony

Opening Lecture

Opening Lecture Date / Time Nov 12 (Sun), 2017, 17:30-18:10 Room Premier Ballroom (2F)  
Chair: Kyung Chul Choi (Chungbuk National University, Korea)    
Benzo(a)pyrene: Complex Characteristics and Chemoprevention
Byung-Mu Lee (Sungkyunkwan University, Korea)

Plenary Lecture 1

Speakers Date / Time Nov 13 (Mon), 2017, 09:00-09:50 Room Premier Ballroom (2F)  
Chair: Jin-Ho Chung (Seoul National University, Korea)  
DNA Damage: Impact on Aging, Neurodegeneration and the Effect of Nutritional Interventions
Jan Hoeijmakers (Erasmus Medical Center, Netherlands)

Symposium 1 :Transcription-Associated Causes of Genome Instability in Cancer and Aging

Speakers Date / Time Nov 13 (Mon), 2017, 10:10-11:50 Room 113 (1F)  
Chair: Priscilla Cooper (Lawrence Berkeley National Laboratory, USA), Wim Vermeulen (Medical Genetics, Erasmus Medical Center, Netherlands)  
Understanding R Loop-Mediated Genome Instability: A New Role for Histones and Chromatin Modifications
Andres Aguilera (University of Seville, Spain)
ATM Activation by Transcription-Blocking Lesion-Induced R-loops
Wim Vermeulen (Medical Genetics, Erasmus Medical Center, Netherlands)
Unexpected Connections Between Transcription-Coupled Repair and Homologous Recombination in Maintenance of Genome Stability
Priscilla Cooper (Lawrence Berkeley National Laboratory, USA)
 
Implication of DNA Double-strand Break Repair in Cancer, Aging and Development
Yoshihisa Matsumoto (Tokyo Institute of Technology, Japan)

Symposium 2 :  Epigenetic Effects of Chemical Exposures and Inflammation

Speakers Date / Time Nov 13 (Mon), 2017, 10:10-11:50 Room 114 (1F)  
Chair: Natalia Tretyakova (University of Minnesota, USA), Keon Wook Kang (Seoul National University, Korea)
 
Inflammation-Mediated Changes in DNA Epigenetic Marks
Natalia Tretyakova (University of Minnesota, USA)
Maternal Exposure to Polybrominated Diphenyl Ethers, Epigenomics and Developmental Changes
Winnie Wan-yee Tang (Johns Hopkins University, USA)
Epigenetic Biomarkers for Early Life Environmental Tobacco Smoke Exposure and Inflammation
Yoon Hee Cho (The University of Montana, USA)
 
Bisphenol-A Exposure Leads to Epigenetic Alterations in the Developmental Programming of Hippocampal Neurogenesis
Hyung Sik Kim (Sung Kyun Kwan University, Korea)

Symposium 3 : Translating DNA Damage to the Clinic: from Early Stages to Diagnosis, Treatment, and Survival of Mutation Related Diseases

Speakers Date / Time Nov 13 (Mon), 2017, 10:10-11:50 Room 115 (1F)  
Chair: Stefano BONASSI (IRCCS San Raffaele Pisana, Italy), Xia Huo (Jinan University, China)  
Biomarkers of DNA Damage in Clinics: The Example of Frailty Status in Elderly
Stefano Bonassi (IRCCS San Raffaele Pisana, Italy)
Analysis of Extracellular Nucleic Acids in Liquid Biopsy: Applicability in Cancer Diagnosis and Prevention
Alberto Izzotti (University of Genoa, Italy)
DNA Damage as a Fundamental Cause of Brain Ageing, Cognitive Decline and Neurodegenerative Diseases
Michael Fenech (CSIRO, Australia)
 
Dietary Folate, One-Carbon-Related Genes, and Gastric Cancer in Korea
Jeongseon Kim (National Cancer Center, Korea)

Symposium 4 :  Genomic and Non-genomic Effects of Air Pollution on Newborns and Children

Speakers Date / Time Nov 13 (Mon), 2017, 10:10-11:50 Room 116 (1F)  
Chair: Hyunok Choi (State University of New York at Albany, USA), Kyuhong Lee (Korea Institute of Toxicology, Korea)  
Multiscale Gene Networks Underlying Air Pollution-Driven Asthma
Hyunok Choi (SUNY Albany, USA)
Analysis of Gene Expression Profile in Newborns from Localities with Different Level of Air Pollution
Katerina Honkova (Czech Academy of Sciences, Czech Republic)
Impact of Air Pollution on the Newborn Genome
Radim Sram (Czech Academy of Sciences, Czech Republic)
 
Effects of Inhaled Substances on Human Health: Health Effects Studies on Children are Highly Needed
Kyuhong Lee (Korea Institute of Toxicology, Korea)

Symposium 5 :  Feedback from the 7th International Workshop on Genotoxicity Tests (IWGT) in Tokyo, Japan

Speakers Date / Time Nov 13 (Mon), 2017, 10:10-11:50 Room 117 (1F)  
Chair: Hans-Joerg Martus (Novartis Institutes for BioMedical Research, Switzerland), David Kirkland (Kirkland Consulting, UK)  
Revisiting the Salmonella Mutagenicity Test
Errol Zeiger (Errol Zeiger consulting, USA)
Tools for Measuring Gene Mutations in Mammalian Cell Cultures
Bhaskar Gollapudi (Exponent Inc, USA)
3D Models for Genotoxicity Testing
Stefan Pfuhler (Procter & Gamble, USA)
In Vivo Genotoxicity Strategies
David Kirkland (Kirkland Consulting, UK)
Risk of Aneugen Exposure
Anthony Lynch (GlaxoSmithKline, UK)

Keynote Lecture 1

Speakers Date / Time Nov 13 (Mon), 2017, 13:00-13:40 Room 113-114 (1F)  
Chair: Young-Joon Surh (Seoul National University, Korea)  
Exploration of Cancer Etiology in Humans -from History of Chemical Carcinogenesis in Animal Models to Future Perspectives-
Hitoshi Nakagama (National Cancer Center, Japan)

Keynote Lecture 2

Speakers Date / Time Nov 13 (Mon), 2017, 13:00-13:40 Room 116-117 (1F)  
Chair: Masamitsu Honma (National Institute of Health Sciences, Japan)  
Arsenic Contamination in Drinking Water and its Toxicity and Carcinogenicity in Human: Are We Safe?
Ashok K. Giri (Indian Inst. of Chemical Biology, India)

Symposium 6 :  Molecular Mechanisms Underlying Thresholds of Genotoxic Carcinogens

Speakers Date / Time Nov 13 (Mon), 2017, 14:00-15:40 Room 113 (1F)  
Chair: Takehiko Nohmi (National Institute of Health Sciences, Japan), George Johnson (Swansea University, UK)  
Introduction: Experimental Approaches to Investigate the Constituents of Genotoxic and Carcinogenic Thresholds
Takehiko Nohmi (NIHS, Japan)
"Effect of Life Stage and Target Tissue on Dose-Response Assessment of Ems-Induced Genotoxicity in Gpt-Delta Mice"
Robert H. Heflich (USFDA/NCTR, USA)
Impact of Mode of Action on Dose Response, Potency and Point of Departure
George Johnson (Swansea University, UK)
DNA Repair System as a Constituent of Mechanism Underlying Practical Threshold of Oxidative Stress-Induced Carcinogenesis
Teruhisa Tsuzuki (Kyushu University, Japan)
Practical Dose-Response Threshold for Environmental Carcinogens and Implications for Regulatory Action
Yasunobu Aoki (National Institute for Environmental Studies, Japan)

Symposium 7 :  Systems Toxicological Approaches for Evaluating Environmental Mutagen

Speakers Date / Time Nov 13 (Mon), 2017, 14:00-15:40 Room 114 (1F)  
Chair: Jung-Hwa Oh (Korea Institute of Toxicology, Korea), Jürgen Borlak (Hannover Medical School, Germany)  
Toxicogenomics Applied to a Short Term Bioassay to Distinguish Between Genotoxic- and Non-Genotoxic Hepatocarcinogens
Jürgen Borlak (Hannover Medical School, Germany)
In Silico Prediction for Genotoxic Drug Impurities; Tools and Data Evaluation
Yong-Moon Lee (Chungbuk National University, Korea)
Assessment of Genotoxicity of PAH Mixtures from Contaminated Areas
Dawoon Jung (Korea Environment Institute, Korea)
 
Impact of NGS on Environmental Mutagen Research
Suzuki Takayoshi (National Institute of Health Sciences, Japan)

Symposium 8 :  Micronuclei and Other Nuclear Anomalies as Biomarkers of Genotoxicity: Mechanisms and Application in Human in vivo Studies

Speakers Date / Time Nov 13 (Mon), 2017, 14:00-15:40 Room 115 (1F)  
Chair: Michael Fenech (CSIRO, Australia), Nina Holland (University of California)  
"Molecular Mechanisms by which Genotoxic Events Lead to the Formation of Micronuclei Nucleoplasmic Bridges and Nuclear Buds"
Michael Fenech (CSIRO, Australia)
"Air Pollution and Cytogenetic Damage Assessed by Micronucleus Assay in Human Blood and Exfoliated Cells "
Nina Holland (University of California, Berkeley, USA)
Micronucleus Cytome Assays as Biomarkers of Exposure to Genotoxic Chemicals in Vivo
Siegfried Knasmueller (Medical University of Vienna, Austria)
"Micronuclei, Nucleoplasmic Bridges and Nuclear Buds as Biomarkers of Disease Risk and Accelerated Ageing"
Stefano Bonassi (San Raffaele University, Italy)
Application of the Exfoliated Buccal Micronucleus Test to Human Biomonitoring and Clinical Studies – Results of Inter-Laboratory Scoring Comparisons and a Meta-analysis
Claudia Bolognesi (Universitaria San Martino-IST Istituto Nazionale Ricerca sul Cancro, Italy)

Symposium 9 :  Risk Assessment of Food-Borne Carcinogens

Speakers Date / Time Nov 13 (Mon), 2017, 14:00-15:40 Room 116 (1F)  
Chair: Margareta Törnqvist (Stockholm University, Sweden), Jan Alexander (Norway)  
Risk Assessment of Carcinogenic Substances in Food
Jan Alexander (Norway)
DNA Adductomics to Unravel the Causal Link Between Red Meat Digestion and Colorectal Cancer
Lynn Vanhaecke (Belgium)
Glycidol Compared to 3-Monochloropropane-1,2-Diol and Acrylamide Using Genotoxic Potency and a Relative Risk Model
Jenny Aasa (Stockholm University, Sweden)
 
Risk Assessment of Carcinogenic Substances in Food by Total Diet Study
Cho-il Kim (Korea Health Industry Development Institute, Korea)

Symposium 10 :  Nutrigenomics and Nutrigenetics

Speakers Date / Time Nov 13 (Mon), 2017, 14:00-15:40 Room 117 (1F)  
Chair: Lucia Regina Ribeiro (Sao Paulo State University- UNESP, Brazil), Bernhard Hennig (University of Kentuckey, USA)  
Nutritional Modulation of Environmental Toxicity: Implications in Inflammatory Diseases
Bernhard Hennig (University of Kentuckey, USA)
Non-canonical And Immunogenic Programmed Cell Death Mechanisms Triggered By Natural Compounds
Marc Diederich (Seoul National University, Korea)
 
Redox Regulation of Lipid Metabolism in Cancer
Huiyong Yin (Institute for Nutritional Sciences, China)
 
Identification of Marliolide and Convallatoxin as NRF2 Activator and Inhibitor
Youngsam Keum (Dongguk University, Korea)

Distinguished Lecture 1

Speakers Date / Time Nov 13 (Mon), 2017, 16:10-16:40 Room Premier Ballroom (2F)  
Chair: Young-Jin Chun (Chung-Ang University, Korea)  
Obesity and DNA Damage
Siegfried Knasmueller (Medical University of Vienna, Austria)

Plenary Lecture 2

Speakers Date / Time Nov 14 (Tue), 2017, 09:00-09:50 Room Premier Ballroom (2F)  
Chair: Takehiko Nohmi (NIHS, Japan)  
Advances in Environmental Carcinogenesis and Mutagenesis: from Chimney Sweeps to Oncogenes
Young-Joon Surh (Seoul National University, Korea)

Symposium 11 :  Botanical Dietary Supplements and Potential Public Health Adverse Effects

Speakers Date / Time Nov 14 (Tue), 2017, 10:10-11:50 Room 113 (1F)  
Chair: Nan Mei (FDA/NCTR, USA), Kyung-Min Lim (Ewha Womans University, Korea)  
Cancer Related Herbs and Dietary Supplements: Online Table of Medical Case reports. Part 5 of 5.
Amy C. Brown (University of Hawaii at Manoa, USA)
Mechanistic Study of Ginkgo Biloba Leaf Extract-Induced Genotoxicity
Mugimane G. Manjanatha (FDA/NCTR, USA)
Role of Hepatic Cytochrome P450 Enzymes in the Detoxication of Aristolochic Acids
Yang Luan (Shanghai Jiaotong University, China)
Involvement of Nrf2 Signaling Pathway in Usnic Acid-Induced Toxicity
Lei Guo (FDA/NCTR, USA)

Symposium 12 :  Mutational Signatures

Speakers Date / Time Nov 14 (Tue), 2017, 10:10-11:50 Room 114 (1F)  
Chair: David Phillips (King’s College London, UK), Donghak Kim (Konkuk University, Korea)  
Signatures of Mutational Processes in Human Cancer
Ludmil Alexandrov (Los Alamos National Laboratory/ Sanger Institute, USA/UK)
Mutational Signatures as Clues to Cancer Aetiology and Carcinogenic Mechanism
David Phillips (King’s College London, UK)
Whole Genome Exome Analysis of Cholangiocarcinoma of Offset Color Proof-Printing Workers
Hitoshi Nakagama (National Cancer Center, Japan)
 
Unravelling the Puzzle of Mutational Signatures in Cancers: A Back-to-the-Bench Call
Jiri Zavadil (International Agency for Research on Cancer (WHO), France)

Symposium 13 :  Intestinal Microbiota and Colorectal Cancer

Speakers Date / Time Nov 14 (Tue), 2017, 10:10-11:50 Room 115 (1F)  
Chair: Keiji Wakabayashi (University of Shizuoka, Japan), Mi-Kyung Sung (Sookmyung Women’s University, Korea  
Gut Microbiota: key modulator for Immunometabolism
GwangPyo Ko (Seoul National University, KoBioLabs, Inc, Korea)
"Novel Genotoxins “Colibactin” Produced by E.Coli and Colon Carcinogenesis (In Vitro, In Vivo Experiments)"
Kenji Watanabe (University of Shizuoka, Japan)
Gut Microbiota and its Role in Colon Tumorigenesis
Satoshi Matsumoto (Yakult Central Institute, Japan)
 
Intestinal Inflammation and Altered Gut Microbiota Compostion: Identification of Modulators
Mi-Kyung Sung (Sookmyung Women’s University, Korea)

Symposium 14 :  In Silico Genetic Toxicity Assessment in International Regulatory Settings

Speakers Date / Time Nov 14 (Tue), 2017, 10:10-11:50 Room 116 (1F)  
Chair: Kyu-Bong Kim (Dankook University, Korea), Mark TD Cronin (Liverpool University, UK)  
AOP-based Evaluation of Chemical Mutagenicity and Development of New Endpoints and Models
Masamitsu Honma (NIHS, Japan)
EFSA Project to Evaluate the Applicability of Existing (Q)SAR Models and Read-Across for Predicting the Genotoxicity of Pesticides
James Rathman (MN-AM, The Ohio State University, USA/ Germany)
Use of In Silico Approaches in Food Contact Notification Process
Kirk Arvidson (US FDA CFSAN, USA)
 
Toxicity Databases of Industrial Chemicals in Japan to Improve In Silico Approaches for Regulatory Safety Assessment
Takashi Yamada (NIHS Division of Risk Assessment, Japan)

Symposium 15 :  Quantitative Analysis of Genetic Toxicology Dose-Response Data for Regulatory Evaluations and Decision-Making

Speakers Date / Time Nov 14 (Tue), 2017 10:10-11:50 Room 117 (1F)  
Chair: Paul White (Health Canada, Canada), John Wills (Health Canada, Environmental Health Science and Research, Canada)  
Genetic Damage as a Relevant Toxicological Endpoint for Regulatory Decision-Making
Paul White (Health Canada, Environmental Health Science and Research, Canada)
Using The Covariate BMD Approach to Quantitatively Assess Genotoxic Potency: Comparing BMDs Derived Across Variants of the Transgenic Rodent Gene Mutation Assay
John Wills (Health Canada, Environmental Health Science and Research, Canada)
Use of the Benchmark-Dose Approach for Determination of Human Exposure Limits in Pharmaceutical Development - Issues and Possible Solutions
Andreas Zeller (Hoffmann La Roche, Switzerland)
Quantitative Approaches to Key Carcinogenic Events Assessment of Genotoxic Carcinogens
Shoji Fukushima (Japan Bioassay Research Center, Japan)

Plenary Lecture 3

Speakers Date / Time Nov 15 (Wed), 2017, 09:00-09:50 Room Premier Ballroom (2F)  
Chair: Sang Geon Kim (Seoul National University, Korea)  
In Silico Approaches in Genetic Toxicology: Progress and Future
Masamitsu Honma (National Institute of Health Sciences, Japan)

Symposium 16 :  The Role of Genetic Toxicity in Thresholds of Toxicological Concern in Cancer Risk Assessment

Speakers Date / Time Nov 15 (Wed), 2017, 10:10-11:50 Room 113 (1F)  
Chair: Chihae Yang (Molecular Networks GmbH, Germany), Kyu-Bong Kim (Dankook University, Korea)
 
Threshold of Toxicological Concern: Significance to Industry
Alan R Boobis (ILSI Europe/Imperial College London, UK)
The CEFIC LRI Project: Update of a New CPDB Database and Point of Departure Analysis
Mark TD Cronin (Liverpool John Moores University, UK)
Genetic Toxicity Mode Of Action and their Relations to Carcinogenicity Based on the Updated Cancer TTC Database
Chihae Yang (Molecular Networks GmbH and Altamira LLC, USA)
 
Application of Threshold of Toxicological Concern (TTC) Approach in Safety Assessment of Consumer Products
Woo-Hyuck Choi (LG Household & Health Care, Korea)

Symposium 17 :  Overview of the Application of Genetic Toxicology to International Tobacco Product Regulation

Speakers Date / Time Nov 15 (Wed), 2017, 10:10-11:50 Room 114 (1F)  
Chair: Carolina Garcia-Canton (British American Tobacco Co, UK), Moo-Yeol Lee (Dongguk University, Korea)
 
Overview of International Regulations and Guidances Related to the Use of Genetic Toxicology Data
Martha Moore (Ramboll Environ, USA)
Historical Use of Genetic Toxicology Data for Tobacco Product Stewardship
Kei Yoshino (Japan Tobacco Inc, Japan)
Overview of General Technical Issues Related to the Use of Genetic Toxicology Assays for Tobacco Product Evaluation
Julie Clements (Covance, UK)
 
Genetic Variations in Tobacco Smoking and Biomarkers
Mihi Yang (Sookmyung Women's University, Korea)

Symposium 18 :  Human Population Exposed to Environmental Mutagen and Carcinogens -1. Arsenic Exposure in Asian Countries and its Genotoxicity and Carcinogenicity-

Speakers Date / Time Nov 15 (Wed), 2017, 10:10-11:50 Room 115 (1F)  
Chair: Ashok K. Giri (Indian Inst. of Chemical Biology, India), Kyoung Sik Moon (Korea Institute of Toxicology, Korea)  
Imprinting of Adipocytokines Following In Utero Arsenic Exposure Leads to Diabetes Associated Nephropathy
Vikas Srivastava (CSIR-Indian Institute of Toxicology Research, India)
Genetic Damage and Epigenetic Changes in Children Exposed to Arsenic Through Drinking Water
Apurba K. Bandyopadhyay (Health Point Multispecialty Hospital, India)
Arsenic Carcinogenesis: Unraveling Mechanisms by the Use of Animal Models
Hideki Wanibuchi (Osaka City University Medical School, Japan)
 
Role of Microrna in Arsenic Induced Health Effects, Susceptibility and Carcinogenicity
Ashok K. Giri (Indian Inst. of Chemical Biology, India)

Symposium 19 :  Human Population Exposed to Environmental Mutagen and Carcinogens -3. Environmental and Occupational Threat on Human Health-

Speakers Date / Time Nov 15 (Wed), 2017, 10:10-11:50 Room 116 (1F)  
Chair: Haruhiko Sugimura (Hamamatsu University School of Medicine, Japan), Kyung-Taek Rim (Occupational Safety and Health Research Institute, Korea)  
Environmental Oxidative Stress, Adaptive Antioxidant Response and Metabolic Diseases
Jingbo Pi (China Medical University, China)
A Challenge in DNA Adductomics of Human Tissue: Does It Reflect Exposures?
Haruhiko Sugimura (Hamamatsu University School of Medicine, Japan)
Human Blood Lymphocytes for Monitoring DNA Damage due to Selected Environmental Mutagens
P. K. Seth (Indian Institute of Toxicology Research, India)
 
Occupational Cancers with Chemical Exposure and their Prevention in Korea: Now and Future
Kyung-Taek Rim (Occupational Safety and Health Research Institute, Korea)

Symposium 20 :  Targeted and Untargeted DNA and Protein Adductomics

Speakers Date / Time Nov 15 (Wed), 2017, 10:10-11:50 Room 117 (1F)  
Chair: David Phillips (King’s College London, UK), Ok-Nam Bae (Hanyang University, Korea)  
Mass Spectrometry in the Analysis of DNA Adducts Associated with Tobacco Use
Peter Villalta (Univ Minnesota, USA)
A High Resolution LC-MS3 Adductomic Approach to Characterize DNA Damage
Silvia Balbo (Univ Minnesota, USA)
Albumin Adductomics for Human Biomonitoring in Epidemiological Research
David Phillips (King’s College London, UK)
 
Fate of Nitrated Aryl Hydrocarbon DNA Adducts to Mutations Revealed through DNA Adductome and Site-specifically Adducted DNA Techniques
Takashi Yagi (Osaka Prefecture University, Japan)

Keynote Lecture 3

Speakers Date / Time Nov 15 (Wed), 2017, 13:00-13:40 Room 113-114 (1F)  
Chair: Soo Jung Sohn (Ministry of Food and Drug Safety, Korea)  
Emerging Concepts and Strategies in Testing for Genomic Damage
Paul White (Health Canada, Canada)

Keynote Lecture 4

Speakers Date / Time Nov 15 (Wed), 2017, 13:00-13:40 Room 116-117 (1F)  
Chair: Sang-Dai Park (Presidential Advisory Council on Science & Technology, Korea)  
Ecological Impacts of Emerging Pollutants in a Coastal Region of China
Yonglong LU (Chinese Academy of Sciences, China)

Symposium 22 :  Aristolochic-Acid Associated Cancers

Speakers Date / Time Nov 15 (Wed), 2017, 14:00-15:40
Room 114 (1F)  
Chair: Steven G Rozen (Duke-NUS Medical School, Singapore), Minsoo Noh (Seoul National University, Korea)
 
Mutational Signatures Indicate That Aristolochic Acids and Their Derivatives Are Extremely Prevalent in Hepatocellular Carcinomas From Taiwan and Pose a Global Health Problem
Steven G. Rozen (Duke-NUS Medical School, Singapore)
Aristolochic Acid-Associated Cancers in Europe: Implications For A Preventable Global Disease
Jiri Zavadil (International Agency for Research on Cancer (WHO), France)
Aristolochic Acid Induced Urothelial Carcinoma: a Disease Enters by Mouth
Kai-Jie Yu (Lin-Kou Chang Gung Memorial Hospital, Taiwan)
 
Aristolochic Acid-Induced DNA Adducts and Mutations in Rats
Nan Mei (FDA/NCTR, USA)

Symposium 23 :  Human Population Exposed to Environmental Mutagen and Carcinogens -2. Air Pollution and Related Human Health and Disease -

Speakers Date / Time Nov 15 (Wed), 2017, 14:00-15:40 Room 115 (1F)  
Chair: Jun Yang (Zhejiang University, China), Young Rok Seo (Dongguk University, Korea)  
Ambient Particulate Induced Lung Function Loss in Patients with Chronic Obstructive Pulmonary Disease
Wei Huang (Peking University Institute of Environmental Medicine, China)
Air Pollution with Mutagens/Carcinogens and its Long-Range Transport
Tetsushi Watanabe (Kyoto Pharmaceutical University, Japan)
Toxicoproteomic Analysis of Metal Rich Ambient Particulate Matter Collected from Steel Iron Industry
P. Rajaguru (Anna University, India)
 
Toxicogenomic Approach for Predicting the Potential Pathogenetic Mechanisms of Inflammatory Disease in the Middle Ear Caused by Exposure to Diesel Exhaust Particles
Young Rok Seo (Dongguk University, Korea)

Symposium 24 :  Human Population Exposed to Environmental Mutagen and Carcinogens -4. Genetic or Epigenetic Mechanism Related to Cancer or Other Diseases-

Speakers Date / Time Nov 15 (Wed), 2017, 14:00-15:40
Room 116 (1F)  
Chair: Yukari Totsuka (National Cancer Center Research Institute, Japan), Kinarm Ko (Konkuk University, Korea)
 
Taurine Inhibits Autophagy via Switch of the Mitochondrial NADH Dehydrogenase Genes to Ameliorate Particulate Matter-Involved Emphysema
Rui Chen (Southeast University, China)
Exploration of Esophageal Cancer Etiology Using DNA Adductome Analysis
Yukari Totsuka (National Cancer Center Research Institute, Japan)
Novel MicroRNA-associated Molecules Responsible for Liver Cancer Progression
Sang Geon Kim (Seoul National University, Korea)
 
Early Life Exposed to E-Waste Pollutants and Adverse Development Outcomes
Xia Huo (Jinan University, China)

Symposium 25 :  Antimutagenesis and Anticarcinogenesis

Speakers Date / Time Nov 15 (Wed), 2017, 14:00-15:40 Room 117 (1F)  
Chair: Zigang Dong (University of Minnesota, USA), Hye-Kyung Na (Sungshin Women’s University, Korea)  
Dietary Phytochemicals for Cancer Chemoprevention
Zigang Dong (University of Minnesota, USA)
Protective Effect of Agaro-oligosaccharides on Gut Dysbiosis and Colon Tumorigenesis in High-fat Diet-fed mice
Yuji Naito (Kyoto Prefectural University, Japan)
15-Keto Prostaglandin E2 Inhibits Proliferation of Breast Cancer Cells Through Suppression of STAT3 Signaling
Hye-Kyung Na (Sungshin Women’s University, Korea)
 
Multi-Omics Approach to Cancer Prevention by Spinach
Roderick Dashwood (Texas A& M University, USA)

Distinguished Lecture 2

Speakers Date / Time Nov 15 (Wed), 2017, 16:10-16:40 Room Premier Ballroom (2F)  
Chair: Byung-Hoon Lee (Seoul National University, Korea)  
Quantitative Genetic Toxicology Developments
George Johnson (Swansea University Medical School, UK)

Plenary Lecture 4

Speakers Date / Time Nov 16 (Thu), 2017, 09:00-09:50 Room Premier Ballroom (2F)  
Chair: Stefano Bonassi (IRCCS San Raffaele Pisana, Italy)  
Genome Health Clinic Concept for Disease Prevention Based on Optimising DNA and Telomere Integrity Using Personalised Diet/Life-Style Intervention
Michael Fenech (CSIRO Health and Biosecurity, Australia)

Symposium 26 :  Application of Genetic Toxicology Assays to Inform the Regulation of Tobacco and Electronic Nicotine Delivery System Products

Speakers Date / Time Nov 16 (Thu), 2017, 10:10-11:50 Room 113 (1F)  
Chair: Martha Moore (Ramboll Environ, USA), Joohee Jung (Duksung Women's University, Korea)  
Chemical Composition, Cytotoxicity and Mutagenicity of Smoke from Korea Commercial Cigarettes with Breakable Capsule in the Filter
Chul-Hoon Park (KT&G, Korea)
The Application Of in Vitro Genetic Toxicology Testing For The Evaluation Of Electrically Heated Tobacco - A Case Study
Carolina Garcia-Canton (British American Tobacco Co, UK)
A Combined in Vivo Micronucleus and Comet Study of an Aerosolized Ends Formulation
Kyeonghee Monica Lee (Altria, USA)

Symposium 27 :  DNA Replication Stress, DNA Damage & Genome Instability

Speakers Date / Time Nov 16 (Thu), 2017, 10:10-11:50 Room 114 (1F)  
Chair: Luis Blanco (Spanish Research Council, Spain), Sung-Keun Lee (Inha University, Korea)  
Human PrimPol, A Novel Primase/Polymerase, Tumor Suppressor and Biotechnological Tool
Luis Blanco (Spanish Research Council, Spain)
Mutational Signatures and Genomic Scars of DNA Break Repair Pathways
Marcel Tijsterman (Leiden University, The Netherlands)
 
Understanding the Interplay between DNA Damage Tolerance Pathways in vivo
Robert Fuchs (CNRS Marseille, France)
 
Requirement of Yeast RAD2, a Homolog of Human XPG Gene, for Efficient Cell Cycle and Mutagenesis Regulation in the Presence of UV Damage : Implications for Cockayne Syndrome
Sung-Keun Lee (Inha University, Korea)

Symposium 28 : Nucleotide Excision Repair: Understanding the Molecular Mechanism of Repair of Environmental Damage to DNA

Speakers Date / Time Nov 16 (Thu), 2017, 10:10-11:50 Room 115 (1F)  
Chair: Kaoru Sugasawa (Kobe University, Japan), Jongsun Park (Chungnam National University, Korea  
Regulation of Dual Incision and Repair Synthesis in Human Nucleotide Excision Repair
Orlando Schärer (UNIST/IBS)
DNA Damage Recognition by Rad4/XPC during Eukaryotic Nucleotide Excision Repair
Jung-Hyun Min (University of Illinois, USA)
Chromatin Dynamics Regulating DNA Damage Recognition of Nucleotide Excision Repair
Kaoru Sugasawa (Kobe University, Japan)
 
Heavy Metal Exposure Disrupts p53-Mediated DNA Repair Activity via Inhibition of Protein-Protein Interactions in vitro & in vivo
Young Rok Seo (Dongguk University, Korea)

Symposium 29 : Environmental Epigenetics

Speakers Date / Time Nov 16 (Thu), 2017, 10:10-11:50 Room 116 (1F)  
Chair: Jinhee Choi (University of Seoul, Korea), Marie-Agnès Coutellec (INRA, Ecology and Ecosystem Health, France)  
Epigenetic Mechanisms in Invertebrates: Review of Current Knowledge and Ecotoxicological Perspectives
Marie-Agnès Coutellec (INRA, Ecology and Ecosystem Health, France)
Epigenetic Mechanisms as Drivers of Environmental Stress Response in Daphnia
Jana Asselman (University of Ghent, Belgium)
H3K27Me3 Epigenetic Mark for Sensitivity to Physiological Adaptation in Elevated Temperature Exposure: A Lesson from the Nematode Caenorhabditis Elegans
Nivedita Chatterjee (University of Seoul, Korea)
 
Particulate Matter Promotes Cellular Senescence in Human Keratinocytes through Epigenetic Regulation of p16INK4A
Jin Won Hyun (Jeju National University, Korea)

Symposium 30 :  Regulation of Cell Death and Survival after Genotoxic Stress

Speakers Date / Time Nov 16 (Thu), 2017, 10:10-11:50 Room 117 (1F)  
Chair: Thomas Hofmann (German Cancer Research Center, Germany), So Hee Kwon (Yonsei University, Korea)
 
"Regulation of DNA Repair and Deathpathways Following Anticancer Drugs and Environmental Carcinogens"
Bernd Kaina (University of Mainz, Institute of Toxicology, Germany)
Mapping the Break-ome in Cancer Cells: New Clues into Genomic Instability and Common Fragile Sites
Rami Aqeilan (Hebrew University of Jerusalem, Israel)
Cellular Decision-Making Between Life and Death by HIPK2 and P53 Upon Genotoxic Damage
Thomas Hofmann (German Cancer Research Center (DKFZ), Germany)
 
A Potent Hydroxamic Acid-based, Small-Molecule Inhibitor A452 Preferentially Inhibits HDAC6 Activity and Induces Cytotoxicity toward Cancer Cells Irrespective of p53 Status
So Hee Kwon (Yonsei University, Korea)
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