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Scientific Program

Plenary Lecture 1

Speakers Date / Time Nov 13 (Mon), 2017, 09:00-09:50 Room Premier Ballroom (2F)  
Chair: Jin-Ho Chung (Seoul National University, Korea)  
DNA Damage: Impact on Aging, Neurodegeneration and the Effect of Nutritional Interventions
Jan Hoeijmakers (Erasmus Medical Center, Netherlands)

Symposium 1:Transcription-Associated Causes of Genome Instability in Cancer and Aging

Speakers Date / Time Nov 13 (Mon), 2017, 10:10-11:50 Room 113 (1F)  
Chair: Priscilla Cooper (Lawrence Berkeley National Laboratory, USA), Wim Vermeulen (Medical Genetics, Erasmus Medical Center, Netherlands)  
Understanding R Loop-Mediated Genome Instability: A New Role for Histones and Chromatin Modifications
Andres Aguilera (University of Seville, Spain)
ATM Activation by Transcription-Blocking Lesion-Induced R-loops
Wim Vermeulen (Medical Genetics, Erasmus Medical Center, Netherlands)
Unexpected Connections Between Transcription-Coupled Repair and Homologous Recombination in Maintenance of Genome Stability
Priscilla Cooper (Lawrence Berkeley National Laboratory, USA)
 
Implication of DNA Double-strand Break Repair in Cancer, Aging and Development
Yoshihisa Matsumoto (Tokyo Institute of Technology, Japan)

Symposium 2:  Epigenetic Effects of Chemical Exposures and Inflammation

Speakers Date / Time Nov 13 (Mon), 2017, 10:10-11:50 Room 114 (1F)  
Chair: Natalia Tretyakova (University of Minnesota, USA), Keon Wook Kang (Seoul National University, Korea)
 
Inflammation-Mediated Changes in DNA Epigenetic Marks
Natalia Tretyakova (University of Minnesota, USA)
Maternal Exposure to Polybrominated Diphenyl Ethers, Epigenomics and Developmental Changes
Winnie Wan-yee Tang (Johns Hopkins University, USA)
Epigenetic Biomarkers for Early Life Environmental Tobacco Smoke Exposure and Inflammation
Yoon Hee Cho (The University of Montana, USA)
 
Bisphenol-A Exposure Leads to Epigenetic Alterations in the Developmental Programming of Hippocampal Neurogenesis
Hyung Sik Kim (Sung Kyun Kwan University, Korea)

Symposium 3 : Translating DNA Damage to the Clinic: from Early Stages to Diagnosis, Treatment, and Survival of Mutation Related Diseases

Speakers Date / Time Nov 13 (Mon), 2017, 10:10-11:50 Room 115 (1F)  
Chair: Stefano BONASSI (IRCCS San Raffaele Pisana, Italy), Xia Huo (Jinan University, China)  
Biomarkers of DNA Damage in Clinics: The Example of Frailty Status in Elderly
Stefano Bonassi (IRCCS San Raffaele Pisana, Italy)
Analysis of Extracellular Nucleic Acids in Liquid Biopsy: Applicability in Cancer Diagnosis and Prevention
Alberto Izzotti (University of Genoa, Italy)
DNA Damage as a Fundamental Cause of Brain Ageing, Cognitive Decline and Neurodegenerative Diseases
Michael Fenech (CSIRO, Australia)
 
Dietary Folate, One-Carbon-Related Genes, and Gastric Cancer in Korea
Jeongseon Kim (National Cancer Center, Korea)

Symposium 4 :  Genomic and Non-genomic Effects of Air Pollution on Newborns and Children

Speakers Date / Time Nov 13 (Mon), 2017, 10:10-11:50 Room 116 (1F)  
Chair: Hyunok Choi (State University of New York at Albany, USA), Kyuhong Lee (Korea Institute of Toxicology, Korea)  
Multiscale Gene Networks Underlying Air Pollution-Driven Asthma
Hyunok Choi (SUNY Albany, USA)
Analysis of Gene Expression Profile in Newborns from Localities with Different Level of Air Pollution
Katerina Honkova (Czech Academy of Sciences, Czech Republic)
Impact of Air Pollution on the Newborn Genome
Radim Sram (Czech Academy of Sciences, Czech Republic)
 
Effects of Inhaled Substances on Human Health: Health Effects Studies on Children are Highly Needed
Kyuhong Lee (Korea Institute of Toxicology, Korea)

Symposium 5 :  Feedback from the 7th International Workshop on Genotoxicity Tests (IWGT) in Tokyo, Japan

Speakers Date / Time Nov 13 (Mon), 2017, 10:10-11:50 Room 117 (1F)  
Chair: Hans-Joerg Martus (Novartis Institutes for BioMedical Research, Switzerland), David Kirkland (Kirkland Consulting, UK)  
Revisiting the Salmonella Mutagenicity Test
Errol Zeiger (Errol Zeiger consulting, USA)
Tools for Measuring Gene Mutations in Mammalian Cell Cultures
Bhaskar Gollapudi (Exponent Inc, USA)
3D Models for Genotoxicity Testing
Stefan Pfuhler (Procter & Gamble, USA)
In Vivo Genotoxicity Strategies
David Kirkland (Kirkland Consulting, UK)
Risk of Aneugen Exposure
Anthony Lynch (GlaxoSmithKline, UK)

Keynote Lecture 1

Speakers Date / Time Nov 13 (Mon), 2017, 13:00-13:40 Room 113-114 (1F)  
Chair: Young-Joon Surh (Seoul National University, Korea)  
Exploration of Cancer Etiology in Humans -from History of Chemical Carcinogenesis in Animal Models to Future Perspectives-
Hitoshi Nakagama (National Cancer Center, Japan)

Keynote Lecture 2

Speakers Date / Time Nov 13 (Mon), 2017, 13:00-13:40 Room 116-117 (1F)  
Chair: Masamitsu Honma (National Institute of Health Sciences, Japan)  
Arsenic Contamination in Drinking Water and its Toxicity and Carcinogenicity in Human: Are We Safe?
Ashok K. Giri (Indian Inst. of Chemical Biology, India)

Symposium 6 :  Molecular Mechanisms Underlying Thresholds of Genotoxic Carcinogens

Speakers Date / Time Nov 13 (Mon), 2017, 14:00-15:40 Room 113 (1F)  
Chair: Takehiko Nohmi (National Institute of Health Sciences, Japan), George Johnson (Swansea University, UK)  
Introduction: Experimental Approaches to Investigate the Constituents of Genotoxic and Carcinogenic Thresholds
Takehiko Nohmi (NIHS, Japan)
"Effect of Life Stage and Target Tissue on Dose-Response Assessment of Ems-Induced Genotoxicity in Gpt-Delta Mice"
Robert H. Heflich (USFDA/NCTR, USA)
Impact of Mode of Action on Dose Response, Potency and Point of Departure
George Johnson (Swansea University, UK)
DNA Repair System as a Constituent of Mechanism Underlying Practical Threshold of Oxidative Stress-Induced Carcinogenesis
Teruhisa Tsuzuki (Kyushu University, Japan)
Practical Dose-Response Threshold for Environmental Carcinogens and Implications for Regulatory Action
Yasunobu Aoki (National Institute for Environmental Studies, Japan)

Symposium 7 :  Systems Toxicological Approaches for Evaluating Environmental Mutagen

Speakers Date / Time Nov 13 (Mon), 2017, 14:00-15:40 Room 114 (1F)  
Chair: Jung-Hwa Oh (Korea Institute of Toxicology, Korea), Jürgen Borlak (Hannover Medical School, Germany)  
Toxicogenomics Applied to a Short Term Bioassay to Distinguish Between Genotoxic- and Non-Genotoxic Hepatocarcinogens
Jürgen Borlak (Hannover Medical School, Germany)
In Silico Prediction for Genotoxic Drug Impurities; Tools and Data Evaluation
Yong-Moon Lee (Chungbuk National University, Korea)
Assessment of Genotoxicity of PAH Mixtures from Contaminated Areas
Dawoon Jung (Korea Environment Institute, Korea)
 
Impact of NGS on Environmental Mutagen Research
Suzuki Takayoshi (National Institute of Health Sciences, Japan)

Symposium 8 :  Micronuclei and Other Nuclear Anomalies as Biomarkers of Genotoxicity: Mechanisms and Application in Human in vivo Studies

Speakers Date / Time Nov 13 (Mon), 2017, 14:00-15:40 Room 115 (1F)  
Chair: Michael Fenech (CSIRO, Australia), Nina Holland (University of California)  
"Molecular Mechanisms by which Genotoxic Events Lead to the Formation of Micronuclei Nucleoplasmic Bridges and Nuclear Buds"
Michael Fenech (CSIRO, Australia)
"Air Pollution and Cytogenetic Damage Assessed by Micronucleus Assay in Human Blood and Exfoliated Cells "
Nina Holland (University of California, Berkeley, USA)
Micronucleus Cytome Assays as Biomarkers of Exposure to Genotoxic Chemicals in Vivo
Siegfried Knasmueller (Medical University of Vienna, Austria)
"Micronuclei, Nucleoplasmic Bridges and Nuclear Buds as Biomarkers of Disease Risk and Accelerated Ageing"
Stefano Bonassi (San Raffaele University, Italy)
Application of the Exfoliated Buccal Micronucleus Test to Human Biomonitoring and Clinical Studies – Results of Inter-Laboratory Scoring Comparisons and a Meta-analysis
Claudia Bolognesi (Universitaria San Martino-IST Istituto Nazionale Ricerca sul Cancro, Italy)

Symposium 9 :  Risk Assessment of Food-Borne Carcinogens

Speakers Date / Time Nov 13 (Mon), 2017, 14:00-15:40 Room 116 (1F)  
Chair: Margareta Törnqvist (Stockholm University, Sweden), Jan Alexander (Norway)  
Risk Assessment of Carcinogenic Substances in Food
Jan Alexander (Norway)
DNA Adductomics to Unravel the Causal Link Between Red Meat Digestion and Colorectal Cancer
Lynn Vanhaecke (Belgium)
Glycidol Compared to 3-Monochloropropane-1,2-Diol and Acrylamide Using Genotoxic Potency and a Relative Risk Model
Jenny Aasa (Stockholm University, Sweden)
 
Risk Assessment of Carcinogenic Substances in Food by Total Diet Study
Cho-il Kim (Korea Health Industry Development Institute, Korea)

Symposium 10 :  Nutrigenomics and Nutrigenetics

Speakers Date / Time Nov 13 (Mon), 2017, 14:00-15:40 Room 117 (1F)  
Chair: Lucia Regina Ribeiro (Sao Paulo State University- UNESP, Brazil), Bernhard Hennig (University of Kentuckey, USA)  
Nutritional Modulation of Environmental Toxicity: Implications in Inflammatory Diseases
Bernhard Hennig (University of Kentuckey, USA)
Non-canonical And Immunogenic Programmed Cell Death Mechanisms Triggered By Natural Compounds
Marc Diederich (Seoul National University, Korea)
 
Redox Regulation of Lipid Metabolism in Cancer
Huiyong Yin (Institute for Nutritional Sciences, China)
 
Identification of Marliolide and Convallatoxin as NRF2 Activator and Inhibitor
Youngsam Keum (Dongguk University, Korea)

Distinguished Lecture 1

Speakers Date / Time Nov 13 (Mon), 2017, 16:10-16:40 Room Premier Ballroom (2F)  
Chair: Young-Jin Chun (Chung-Ang University, Korea)  
Obesity and DNA Damage
Siegfried Knasmueller (Medical University of Vienna, Austria)
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