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Scientific Program

Plenary Lecture 2

Speakers Date / Time Nov 14 (Tue), 2017, 09:00-09:50 Room Premier Ballroom (2F)  
Chair: Takehiko Nohmi (NIHS, Japan)  
Advances in Environmental Carcinogenesis and Mutagenesis: from Chimney Sweeps to Oncogenes
Young-Joon Surh (Seoul National University, Korea)

Symposium 11 :  Botanical Dietary Supplements and Potential Public Health Adverse Effects

Speakers Date / Time Nov 14 (Tue), 2017, 10:10-11:50 Room 113 (1F)  
Chair: Nan Mei (FDA/NCTR, USA), Kyung-Min Lim (Ewha Womans University, Korea)  
Cancer Related Herbs and Dietary Supplements: Online Table of Medical Case reports. Part 5 of 5.
Amy C. Brown (University of Hawaii at Manoa, USA)
Mechanistic Study of Ginkgo Biloba Leaf Extract-Induced Genotoxicity
Mugimane G. Manjanatha (FDA/NCTR, USA)
Role of Hepatic Cytochrome P450 Enzymes in the Detoxication of Aristolochic Acids
Yang Luan (Shanghai Jiaotong University, China)
Involvement of Nrf2 Signaling Pathway in Usnic Acid-Induced Toxicity
Lei Guo (FDA/NCTR, USA)

Symposium 12 :  Mutational Signatures

Speakers Date / Time Nov 14 (Tue), 2017, 10:10-11:50 Room 114 (1F)  
Chair: David Phillips (King’s College London, UK), Donghak Kim (Konkuk University, Korea)  
Signatures of Mutational Processes in Human Cancer
Ludmil Alexandrov (Los Alamos National Laboratory/ Sanger Institute, USA/UK)
Mutational Signatures as Clues to Cancer Aetiology and Carcinogenic Mechanism
David Phillips (King’s College London, UK)
Whole Genome Exome Analysis of Cholangiocarcinoma of Offset Color Proof-Printing Workers
Hitoshi Nakagama (National Cancer Center, Japan)
 
Unravelling the Puzzle of Mutational Signatures in Cancers: A Back-to-the-Bench Call
Jiri Zavadil (International Agency for Research on Cancer (WHO), France)

Symposium 13 :  Intestinal Microbiota and Colorectal Cancer

Speakers Date / Time Nov 14 (Tue), 2017, 10:10-11:50 Room 115 (1F)  
Chair: Keiji Wakabayashi (University of Shizuoka, Japan), Mi-Kyung Sung (Sookmyung Women’s University, Korea  
Gut Microbiota: key modulator for Immunometabolism
GwangPyo Ko (Seoul National University, KoBioLabs, Inc, Korea)
"Novel Genotoxins “Colibactin” Produced by E.Coli and Colon Carcinogenesis (In Vitro, In Vivo Experiments)"
Kenji Watanabe (University of Shizuoka, Japan)
Gut Microbiota and its Role in Colon Tumorigenesis
Satoshi Matsumoto (Yakult Central Institute, Japan)
 
Intestinal Inflammation and Altered Gut Microbiota Compostion: Identification of Modulators
Mi-Kyung Sung (Sookmyung Women’s University, Korea)

Symposium 14 :  In Silico Genetic Toxicity Assessment in International Regulatory Settings

Speakers Date / Time Nov 14 (Tue), 2017, 10:10-11:50 Room 116 (1F)  
Chair: Kyu-Bong Kim (Dankook University, Korea), Mark TD Cronin (Liverpool University, UK)  
AOP-based Evaluation of Chemical Mutagenicity and Development of New Endpoints and Models
Masamitsu Honma (NIHS, Japan)
EFSA Project to Evaluate the Applicability of Existing (Q)SAR Models and Read-Across for Predicting the Genotoxicity of Pesticides
James Rathman (MN-AM, The Ohio State University, USA/ Germany)
Use of In Silico Approaches in Food Contact Notification Process
Kirk Arvidson (US FDA CFSAN, USA)
 
Toxicity Databases of Industrial Chemicals in Japan to Improve In Silico Approaches for Regulatory Safety Assessment
Takashi Yamada (NIHS Division of Risk Assessment, Japan)

Symposium 15 :  Quantitative Analysis of Genetic Toxicology Dose-Response Data for Regulatory Evaluations and Decision-Making

Speakers Date / Time Nov 14 (Tue), 2017 10:10-11:50 Room 117 (1F)  
Chair: Paul White (Health Canada, Canada), John Wills (Health Canada, Environmental Health Science and Research, Canada)  
Genetic Damage as a Relevant Toxicological Endpoint for Regulatory Decision-Making
Paul White (Health Canada, Environmental Health Science and Research, Canada)
Using The Covariate BMD Approach to Quantitatively Assess Genotoxic Potency: Comparing BMDs Derived Across Variants of the Transgenic Rodent Gene Mutation Assay
John Wills (Health Canada, Environmental Health Science and Research, Canada)
Use of the Benchmark-Dose Approach for Determination of Human Exposure Limits in Pharmaceutical Development - Issues and Possible Solutions
Andreas Zeller (Hoffmann La Roche, Switzerland)
Quantitative Approaches to Key Carcinogenic Events Assessment of Genotoxic Carcinogens
Shoji Fukushima (Japan Bioassay Research Center, Japan)
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